The recognition of mindfulness-based interventions as an effective approach to address psychological distress and improve well-being has stimulated the development a multitude programs, each designed for specific applications. While many are focused on addressing particular needs, so-called second-generation typically include overtly spiritual content but also remain secular in their delivery. More recently, explicitly religion-themed mindfulness programs have emerged that yet be evaluated scientifically, raising questions how this occur most appropriate manner. Referring doctrinal charts Won Buddhism, we illustrate example distinction can made transparent between subjected scientific inquiry related religious personal beliefs. By delineating elements belief from practice, areas identified open verification without causing offense. Program participants other practitioners then clearly identify aspects which there is widely accepted evidence effectiveness, may communicated science-based Buddhist practices.